cough causes it all and when it goes away things are relatively normal although a normal cough stays with me for weeks after. Interaction between DM and Tylenol: There is no known interaction between DM and Tylenol in our records. However, an interaction may still exist. Always consult your doctor before taking these medications together. I have a cough and I have been told my a registered nurse who I live with to Tylenol but I have been taking for my cough anyways. Advil, the brand name for the NSAID ibuprofen and guaifenesin, the expectorant, marketed as are often combined in other over-the-counter cold remedies. This Site Might Help You. RE: DM and other Meds? I am taking DM, and I#39;m wondering if I Ibuprofen and/or Nyquil all together, and if not, which combinations with each other?